Trial Name: A radomised controlled trial of standard and low dose Avastin® for Neovascular Macular Degeneration in the East Midlands (TANDEM).
Chief Investigator: Alexander Foss, Nottingham University Hospitals NHS Trust
Trial Description: Wet, or neovascular age-related, macular degeneration causes severe sight loss in older people. It is a common condition, with about 25,000 newly affected people each year in the UK. Treatment with Lucentis® (Ranibizumab) or Eyelea® (Afibercept) is now recommended best practice. Although they prevent sight loss in 90% of patients with wet macular degeneration when given as injections into the eye, Lucentis® and Eyelea® are both quite expensive. Another drug, which has similar properties to Lucentis® is Avastin® (Bevacizumab). Avastin® is currently licensed for colorectal cancer therapy but can also be used for wet macular degeneration, and is a cheaper alternative to Lucentis®.
This is a factorial trial comparing standard versus low-dose Avastin®, and monthly versus two-monthly review intervals. Recruitment finished on 31 October 2016 with a total of 812 randomised participants. The primary outcome is time to treatment failure. Following additional work on the verification of the primary endpoint, result analysis was completed in 2019.
Contact: Beki Haydock
Funding: NHS England and Care Commissioning Groups
Status: Analysis and Reporting
Further Information: Email Beki Haydock (Trial Manager) firstname.lastname@example.org